13-Benzyl-4,11-dihydroxy-1,8-diphenyl-2,9-dithia-13-azadispiro[4.1.4.3]tetradecan-6-one

13-18 Vincenzo Patruno.qxd:-

Sleep breathing disorders (SBD) are commonly divided in three syndromes: obstructive sleep apnea syndrome (OSA), central sleep apnea-hypopnea syndrome (CSA) and Cheyne-Stokes breathing syndrome (CSR), the latter two both characterized by cyclic non-obstructive breathing patterns. Because the prevalence of CSA-CSR in chronic heart failure (CHF) population has been reported from 40% to 60%, CSA-C...

Cover vol. 13, no. 6, December 2016-

Ultrafast excited state dynamics and spectroscopy of 13 , 13 0 - diphenyl - b - carotene w

Ultrafast transient broadband absorption spectroscopy based on the Pump–Supercontinuum Probe (PSCP) technique has been applied to characterize the excited state dynamics of the newlysynthesized artificial b-carotene derivative 13,130-diphenyl-b-carotene in the wavelength range 340–770 nm with ca. 60 fs cross-correlation time after excitation to the S2 state. The influence of phenyl substitution...

1-Benzyl-2,5-diphenyl-3-tosylimidazol­idin-4-one

In the title compound, C(29)H(26)N(2)O(3)S, the central imidazolidine ring adopts an envelope conformation with the N atom bearing the benzyl ring at the flap. The S atom has distorted tetra-hedral geometry. The benzyl and tosyl rings are oriented at a dihedral angle of 52.1 (1)°. The phenyl rings connected to the imidazolidine ring form a dihedral angle of 28.7 (1)°.

CNS Drugs 2004; 18 (13): 827-844

Treating dementia has become a major challenge in clinical practice. Presently, Abstract acetylcholinesterase inhibitors are the first-line drugs in the treatment of Alzheimer's disease (AD). These options are now complemented by memantine, which is approved for the treatment of moderate-to-severe AD. Altogether, a minimum of six agent classes already exist, all of which are approved for clinic...